Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac failure congestive02.05.01.002--Not Available
Cardiac tamponade02.06.01.0010.004405%
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.001970%Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000328%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.006895%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.036502%Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.063563%Not Available
Cheyne-Stokes respiration22.02.01.0240.002517%Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.0010.001888%Not Available
Cholecystitis09.03.01.0010.002517%
Cholecystitis acute09.03.01.0030.004405%Not Available
Cholelithiasis09.03.01.0020.005035%Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.0010.001888%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.001259%Not Available
Colitis07.08.01.001--
Coma17.02.09.0010.006923%Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.002517%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Conduction disorder02.03.01.0080.001259%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coronary artery disease24.04.04.006; 02.02.01.0010.011957%Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.0060.011957%Not Available
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