Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.0110.005664%Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.005664%Not Available
Atrial fibrillation02.03.03.0020.016992%
Atrioventricular block02.03.01.0020.015734%Not Available
Atrioventricular block complete02.03.01.0030.011957%
Atrioventricular block first degree02.03.01.0040.001259%
Atrioventricular block second degree02.03.01.0050.002517%
Back pain15.03.04.005--
Bleeding time prolonged13.01.02.0020.002517%Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.002--
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.0020.043425%Not Available
Brain herniation12.01.10.001; 17.11.01.0020.000493%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.011328%
Bundle branch block left02.03.01.0070.001259%Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cardiac arrest02.03.04.0010.008209%
Cardiac failure02.05.01.0010.002791%
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