Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain contusion24.07.06.020; 17.11.01.010; 12.01.10.0140.001259%Not Available
Cardiac ventricular thrombosis24.01.05.006; 02.01.01.0150.001888%Not Available
Coronary artery restenosis24.04.04.023; 12.02.01.024; 08.07.05.004; 02.02.01.0160.009440%Not Available
Bladder mass20.03.01.0180.001259%Not Available
Coronary artery perforation12.02.01.022; 02.02.01.0140.001259%Not Available
Arterial stenosis24.04.02.0120.001259%Not Available
Traumatic intracranial haemorrhage24.07.04.034; 17.08.05.005; 12.01.10.0170.000493%Not Available
Platelet function test abnormal13.01.04.0060.005035%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.001259%Not Available
Apparent death08.01.03.0620.001888%Not Available
Brain midline shift17.11.01.0110.001259%Not Available
Eye contusion06.11.01.011; 24.07.06.022; 12.01.04.0240.001888%Not Available
Internal haemorrhage24.07.01.0720.003776%Not Available
Vascular stent occlusion24.04.02.026; 08.07.05.0050.009440%Not Available
Vascular stent stenosis08.07.05.007; 24.04.02.0280.006293%Not Available
Vascular stent restenosis24.04.02.027; 08.07.05.0060.007552%Not Available
The 17th Page    First    Pre   17    Total 17 Pages