| Pharmaceutical Information |
| Drug Name |
Ticagrelor |
| Drug ID |
BADD_D02214 |
| Description |
Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207].
Ticagrelor was granted EMA approval on 3 December 2010.[L14207]
Ticagrelor was granted FDA approval on 20 July 2011.[L14201] |
| Indications and Usage |
Ticagrelor is indicated to reduce the risk of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction.[L14201] Ticagrelor is also indicated to reduce the risk of a first myocardial infarction or stroke in high risk patients with coronary artery disease.[L14201] |
| Marketing Status |
approved |
| ATC Code |
B01AC24 |
| DrugBank ID |
DB08816
|
| KEGG ID |
D09017
|
| MeSH ID |
D000077486
|
| PubChem ID |
9871419
|
| TTD Drug ID |
D0WF7L
|
| NDC Product Code |
53747-092; 69037-0007; 76072-1016; 0186-0777; 45941-3055; 50379-0011; 50923-0314; 58623-0131; 69238-1134; 49587-109; 50379-0023; 55154-9618; 15894-0030; 83137-0001; 17228-0776; 49187-0205; 17228-0777; 17228-7777; 62147-0280; 82712-1001; 0186-0776; 55111-969; 65372-1198 |
| UNII |
GLH0314RVC
|
| Synonyms |
Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol |
|
| Chemical Information |
| Molecular Formula |
C23H28F2N6O4S |
| CAS Registry Number |
274693-27-5 |
| SMILES |
CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
|
