Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiagabine hydrochloride
Drug ID BADD_D02211
Description Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Indications and Usage For the treatment of partial seizures
Marketing Status Prescription; Discontinued
ATC Code N03AG06
DrugBank ID DB00906
KEGG ID D02097
MeSH ID D000078308
PubChem ID 91274
TTD Drug ID D0ED7U
NDC Product Code 63459-412; 0093-5031; 63459-404; 16714-154; 63459-402; 63459-416; 0093-8072; 69766-061; 72205-087; 29902-0004; 16714-153; 62756-224; 0093-5030; 62756-200; 72205-084; 16714-152; 72205-086; 72205-085; 16714-151; 0093-8076
Synonyms Tiagabine | N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid | Gabitril | NO 329 | NO-329 | Tiagabine Hydrochloride | (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride | Tiagabine, (S)-isomer | NO 328 | NO-328
Chemical Information
Molecular Formula C20H26ClNO2S2
CAS Registry Number 145821-59-6
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Musculoskeletal stiffness15.03.01.005--Not Available
Affect lability19.04.01.001--Not Available
Haemorrhage24.07.01.002--Not Available
Paraesthesia oral17.02.06.008; 07.05.03.003--Not Available
Erectile dysfunction19.08.04.001; 21.03.01.007--
Red blood cell abnormality01.07.02.006--Not Available
Urinary tract obstruction20.08.01.004--
Psychotic disorder19.03.01.002--
Hyperlipidaemia14.08.03.001--
Skin mass23.07.04.014--Not Available
Language disorder19.19.01.006; 17.02.08.015--Not Available
Anal incontinence17.05.01.021; 07.01.06.029--
Depersonalisation/derealisation disorder19.14.01.004--Not Available
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