Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiagabine hydrochloride
Drug ID BADD_D02211
Description Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Indications and Usage For the treatment of partial seizures
Marketing Status Prescription; Discontinued
ATC Code N03AG06
DrugBank ID DB00906
KEGG ID D02097
MeSH ID D000078308
PubChem ID 91274
TTD Drug ID D0ED7U
NDC Product Code 63459-412; 0093-5031; 63459-404; 16714-154; 63459-402; 63459-416; 0093-8072; 69766-061; 72205-087; 29902-0004; 16714-153; 62756-224; 0093-5030; 62756-200; 72205-084; 16714-152; 72205-086; 72205-085; 16714-151; 0093-8076
Synonyms Tiagabine | N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid | Gabitril | NO 329 | NO-329 | Tiagabine Hydrochloride | (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride | Tiagabine, (S)-isomer | NO 328 | NO-328
Chemical Information
Molecular Formula C20H26ClNO2S2
CAS Registry Number 145821-59-6
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin cancer23.08.02.002; 16.03.02.002--Not Available
Skin discolouration23.03.03.005--Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Smear cervix abnormal13.20.02.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Stomatitis07.05.06.005--
Stupor17.02.04.007; 19.02.05.004--Not Available
Sudden death08.04.01.003; 02.03.04.013--
Suicide attempt19.12.01.004--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendinous contracture15.07.01.001--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tooth abscess07.09.01.003; 11.01.04.003--Not Available
Tremor17.01.06.002--
Urethritis20.07.02.001; 11.01.14.008--
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
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