Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiagabine
Drug ID BADD_D02210
Description Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Indications and Usage For the treatment of partial seizures
Marketing Status Prescription; Discontinued
ATC Code N03AG06
DrugBank ID DB00906
KEGG ID D08588
MeSH ID D000078308
PubChem ID 60648
TTD Drug ID D0ED7U
NDC Product Code 69238-1105; 69238-1106; 69238-1104; 69238-1107
Synonyms Tiagabine | N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid | Gabitril | NO 329 | NO-329 | Tiagabine Hydrochloride | (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride | Tiagabine, (S)-isomer | NO 328 | NO-328
Chemical Information
Molecular Formula C20H25NO2S2
CAS Registry Number 115103-54-3
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Smear cervix abnormal13.20.02.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Stomatitis07.05.06.005--
Stupor19.02.05.004; 17.02.04.007--Not Available
Sudden death08.04.01.003; 02.03.04.013--
Suicide attempt19.12.01.004--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendinous contracture15.07.01.001--Not Available
Tension19.06.02.005--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Tooth abscess11.01.04.003; 07.09.01.003--Not Available
Tremor17.01.06.002--
Urethritis20.07.02.001; 11.01.14.008--
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vaginal infection11.01.10.002; 21.14.02.002--
Vaginal inflammation21.14.02.001--
Vertigo17.02.12.002; 04.04.01.003--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
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