Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thiothixene
Drug ID BADD_D02204
Description A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Indications and Usage For the management of schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AF04
DrugBank ID DB01623
KEGG ID D00374
MeSH ID D013888
PubChem ID 5454
TTD Drug ID D0E0LQ
NDC Product Code 60219-1675; 58159-042; 60219-1676; 53808-1129; 70518-1703; 51407-278; 70518-2544; 51079-589; 60219-1673; 0378-5010; 51407-276; 70954-015; 70518-3147; 60219-1674; 70518-2340; 70518-2594; 51407-277; 0378-2002; 0378-1001; 0378-3005; 70954-014; 51407-275; 70954-017; 48954-575; 70954-016; 51079-588
Synonyms Thiothixene | Tiotixene | Navane
Chemical Information
Molecular Formula C23H29N3O2S2
CAS Registry Number 5591-45-7
SMILES CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ParkinsonismNADH-ubiquinone oxidoreductase chain 1P03886Not Available8098932; 9309697
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Salivary hypersecretion07.06.01.009--Not Available
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tardive dyskinesia17.01.02.012--Not Available
Throat tightness22.02.05.015; 19.01.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tongue movement disturbance17.02.05.049; 07.14.02.016--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Brain oedema17.07.02.003; 12.01.10.010--
Transaminases increased13.03.01.015--Not Available
Blood alkaline phosphatase increased13.04.02.004--
CSF test abnormal13.07.02.005--Not Available
Lactation disorder21.05.02.004; 18.06.02.003--
Abnormal behaviour19.01.01.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
The 3th Page    First    Pre   3    Total 3 Pages