Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thalidomide
Drug ID BADD_D02192
Description A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
Indications and Usage For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
Marketing Status Prescription
ATC Code L04AX02
DrugBank ID DB01041
KEGG ID D00754
MeSH ID D013792
PubChem ID 5426
TTD Drug ID D0U7GK
NDC Product Code 59572-205; 59572-210; 59572-220; 59572-215; 69988-0052; 63818-0424; 17337-0301; 68554-0011
Synonyms Thalidomide | Sedoval | Thalomid
Chemical Information
Molecular Formula C13H10N2O4
CAS Registry Number 50-35-1
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Deep vein thrombosisThrombomodulinP07204T0858315235749; 7878634
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anosmia17.04.04.001; 22.04.03.0060.001737%
Anxiety19.06.02.002--
Aortic stenosis24.04.01.0010.000453%Not Available
Aphasia19.21.01.001; 17.02.03.0010.002895%
Aphthous ulcer07.05.06.0020.002316%Not Available
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Arterial thrombosis24.01.01.0020.001737%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.0030.003474%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.037634%Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.0030.001158%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.0030.001158%
Atypical pneumonia22.07.01.010; 11.01.09.0120.001158%Not Available
B-cell lymphoma16.28.01.001; 01.15.01.0010.000302%Not Available
Back disorder15.03.01.0140.002316%Not Available
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.0010.002316%Not Available
Benign neoplasm of skin23.10.01.006; 16.26.01.006--Not Available
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
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