Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetradecyl hydrogen sulfate (ester)
Drug ID BADD_D02182
Description Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins [L2031]. Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a 1% solution into spider angiomas in 144 patients was made. Also noted was an unspecified number of episodes of epidermal necrosis without significant long-term effects and a 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035].
Indications and Usage For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
Marketing Status Prescription; Discontinued
ATC Code C05BB04
DrugBank ID DB11328
KEGG ID D06882
MeSH ID D012981
PubChem ID 8771
TTD Drug ID D0Z5SM
NDC Product Code 50090-4529; 67457-163; 67457-162; 50090-4525
Synonyms Sodium Tetradecyl Sulfate | Sulfate, Sodium Tetradecyl | Tetradecyl Sulfate, Sodium | Tergitol 4 | Trombavar | Trombovar | Sotradecol Sodium | Sotradecol
Chemical Information
Molecular Formula C14H30O4S
CAS Registry Number 300-52-7
SMILES CCCCC(CC)CCC(CC(C)C)OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Headache17.14.01.001--
Nausea07.01.07.001--
Necrosis08.03.03.001; 24.04.02.006--Not Available
Skin discolouration23.03.03.005--Not Available
Skin exfoliation23.03.07.003--Not Available
Ulcer08.03.06.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Seasonal allergy06.04.01.013; 22.04.04.008; 10.01.04.001--Not Available
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