Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone cypionate
Drug ID BADD_D02171
Description Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.
Indications and Usage Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.[L1153]
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB13943
KEGG ID D00957
MeSH ID C016131
PubChem ID 441404
TTD Drug ID Not Available
NDC Product Code 62756-016; 0574-0820; 69097-536; 76420-065; 46439-8736; 48087-0096; 0409-6562; 71205-289; 51927-2706; 0009-0086; 0143-9659; 50090-0330; 51552-0104; 0009-0417; 0009-0347; 0143-9726; 0591-4128; 0409-6557; 72833-678; 60870-0252; 69097-802; 50090-4147; 62991-3132; 0517-1830; 64025-0021; 62756-017; 0143-9005; 52536-625; 51927-0189; 65089-0049; 50090-4920; 0009-0027; 63629-8705; 0574-0827; 50090-4921; 69097-537; 43647-678; 63187-647; 0009-0085; 50090-4446; 38779-0164; 63275-9982; 63629-8706; 82393-114; 46204-0371; 49803-006; 62756-015; 49452-7660; 0395-8137; 22552-0010
Synonyms testosterone 17 beta-cypionate | testosterone cypionate | testosterone 17 beta-cyclopentanepropionate | testosterone 17 beta-cyclopentylpropionate | Depo-Testosterone | Depo-Testosterone Cypionate | deposteron | Duratest | Testa-C | Testex Elmu | Andronate | Depostomead
Chemical Information
Molecular Formula C27H40O3
CAS Registry Number 58-20-8
SMILES CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=CC(=O)CCC35C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Acne23.02.01.0010.001913%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.016264%Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.0010.003348%
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anger19.04.02.0010.001435%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.003348%
Angina unstable24.04.04.004; 02.02.02.0040.000957%Not Available
Anxiety19.06.02.0020.005262%
Aphasia17.02.03.001; 19.21.01.0010.000957%
Arrhythmia02.03.02.0010.000250%Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000250%Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.0030.000957%Not Available
Asthenia08.01.01.0010.005740%Not Available
Atrial fibrillation02.03.03.0020.004305%
Atrial flutter02.03.03.0030.001435%
Azoospermia21.03.03.001--
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.0010.002392%Not Available
Blindness unilateral06.02.02.009; 17.17.01.0160.000957%Not Available
Blood calcium13.11.01.041--Not Available
Blood calcium decreased13.11.01.002--Not Available
Blood chloride13.11.01.042--Not Available
Blood glucose increased13.02.02.0020.000957%Not Available
Blood phosphorus13.11.01.023--Not Available
Blood potassium13.11.01.032--Not Available
Blood potassium abnormal13.11.01.024--Not Available
Blood testosterone decreased13.10.05.0040.003348%Not Available
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