Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone
Drug ID BADD_D02170
Description Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.[A187114,L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone was isolated from samples and also synthesized in 1935.[A186943]
Indications and Usage To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB00624
KEGG ID D00075
MeSH ID D013739
PubChem ID 6013
TTD Drug ID D06XMU
NDC Product Code 48087-0113; 69238-1013; 49452-7652; 66887-004; 63629-2125; 0591-2114; 63629-2124; 0832-1120; 65089-0050; 63629-8455; 16714-967; 0603-7831; 0591-2363; 42667-5511; 49884-418; 82393-113; 24979-078; 76420-684; 43598-304; 38779-2598; 66887-001; 44132-008; 0832-1121; 64025-0010; 22552-0009; 0023-5990; 0051-8462; 38779-0163; 60870-0251; 45802-754; 70492-002; 51927-1026; 0591-2924; 71589-013; 0591-2921; 0591-2926; 51552-0029; 62332-488; 16714-968; 0245-0872; 44132-006; 0245-0871; 45802-366; 49452-7657; 0591-2925; 0051-8425; 76420-687; 68382-362; 76420-686; 0591-3216; 60592-721; 24979-130; 12875-8248; 45802-610; 76003-1083; 38779-2936; 0009-0074; 49884-510; 68180-943; 43647-568; 0051-8450; 0802-8068; 71589-011; 62991-2150; 69097-363; 0023-5992; 0009-5020; 0591-3524; 69339-158; 43742-1242; 76420-685; 70700-112; 68180-941; 63481-183; 43742-1436; 43742-0677; 63629-2352; 76420-699; 51552-0564; 16714-969; 0591-3217; 45802-281; 62332-552
Synonyms Testosterone | 17-beta-Hydroxy-4-Androsten-3-one | 17 beta Hydroxy 4 Androsten 3 one | Androtop | Histerone | Sterotate | Sustanon | Androderm | Testoderm | Testolin | Testopel | Testosterone Sulfate | AndroGel | 8-Isotestosterone | 8 Isotestosterone | 17-beta-Hydroxy-8 alpha-4-Androsten-3-one | 17 beta Hydroxy 8 alpha 4 Androsten 3 one | Andropatch | Testim
Chemical Information
Molecular Formula C19H28O2
CAS Registry Number 58-22-0
SMILES CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral venous thrombosis17.08.03.002; 24.01.04.0050.000594%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.368129%
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.001007%Not Available
Cheilitis23.03.03.025; 07.05.01.001--
Chest discomfort08.01.08.019; 22.02.08.001; 02.02.02.009--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.020485%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholelithiasis09.03.01.002--Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Clitoral engorgement21.08.02.006--Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.004--Not Available
Clumsiness17.01.02.0050.000594%Not Available
Coagulopathy01.01.02.0010.002672%Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Coordination abnormal17.02.02.004--Not Available
Coronary artery disease24.04.04.006; 02.02.01.0010.040375%Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.0060.005047%Not Available
Coronary artery stenosis02.02.01.010; 24.04.04.0170.003266%Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.0070.001471%Not Available
Cough22.02.03.001--
Crying19.04.02.002; 12.02.11.001; 17.02.05.013; 08.01.03.005--Not Available
Cyst16.02.02.002; 08.03.05.001--Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
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