Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Teriflunomide
Drug ID BADD_D02165
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Indications and Usage Used in the treatment of relapsing forms of multiple sclerosis (MS).
Marketing Status Prescription
ATC Code L04AA31
DrugBank ID DB08880
KEGG ID D10172
MeSH ID C527525
PubChem ID 54684141
TTD Drug ID Not Available
NDC Product Code 69238-1303; 65727-058; 12579-186; 69238-1304; 66499-0059; 59285-001; 69539-032; 47621-049; 17337-0070; 69037-0016; 58468-0211; 63850-8081; 12579-185; 46708-888; 12579-191; 53747-061; 69539-033; 14501-0086; 58468-0210; 59651-036; 66039-916; 0115-1565; 12579-190
Synonyms teriflunomide | (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | (2Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide | RS 61980 | Aubagio | HMR1726 | HMR-1726 | A 771726 | A 1726 | A771726 | A-771726 | A77 1726
Chemical Information
Molecular Formula C12H9F3N2O2
CAS Registry Number 163451-81-8
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.002--
Blood creatine phosphokinase increased13.04.01.0010.004632%
Blood creatinine increased13.13.01.004--
Blood glucose abnormal13.02.02.0080.001158%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.001737%
Blood potassium decreased13.11.01.0100.004053%Not Available
Blood potassium increased13.11.01.0110.002316%Not Available
Blood pressure abnormal13.14.03.0010.002895%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.0050.026634%Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.002895%Not Available
Body temperature increased13.15.01.0010.001737%Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.024897%Not Available
Breast cyst21.05.01.006; 16.14.01.0040.001158%Not Available
Breast mass21.05.04.0020.001158%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.009843%
Bronchopulmonary aspergillosis22.07.08.001; 11.03.01.0020.001158%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.016212%Not Available
Bursitis15.04.01.0010.002316%Not Available
C-reactive protein increased13.09.01.0070.005790%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
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