Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Terbutaline sulfate
Drug ID BADD_D02163
Description Terbutaline was first synthesized in 1966[A230333] and described in the literature in the late 1960s and early 1970s.[A230328] It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098] Terbutaline was granted FDA approval on 25 March 1974.[L32088]
Indications and Usage For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.
Marketing Status Prescription; Discontinued
ATC Code R03AC03; R03CC03
DrugBank ID DB00871
KEGG ID D00688
MeSH ID D013726
PubChem ID 441334
TTD Drug ID D0M8RC
NDC Product Code 62559-721; 62559-722; 51927-2765; 12828-0053; 0143-9375; 0143-9746; 62991-1152; 0404-9962; 72843-101; 49452-7631; 17478-933; 71205-938; 71872-7080; 0527-1311; 24979-132; 0115-2611; 0115-2622; 24979-133; 53104-7513; 71872-7130; 71205-939; 69826-0001; 67296-1053; 63323-665; 0527-1318; 52584-665
Synonyms Terbutaline | Asthmoprotect | Brethaire | Brethine | Bricanyl | Terbasmin | Bricanyl SA | Butaliret | Butalitab | Contimit | KWD-2019 | KWD 2019 | KWD2019 | Monovent | Taziken | Tedipulmo | Terbul | Terbutalin AL | Terbutalin Stada | terbutalin von ct | Terbutalin-ratiopharm | Terbutalin ratiopharm | Terbutaline Sulfate | Terbuturmant | Arubendol
Chemical Information
Molecular Formula C24H40N2O10S
CAS Registry Number 23031-32-5
SMILES CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T52522Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.008--Not Available
Hypertonia15.05.04.007; 17.05.02.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Ventricular extrasystoles02.03.04.007--Not Available
Vomiting07.01.07.003--
Hepatic enzyme increased13.03.01.019--Not Available
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