Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir
Drug ID BADD_D02154
Description Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate.[A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog.[A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain oral bioavailability.[A18473, A178360]
Indications and Usage Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.[A178330] To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
Marketing Status experimental; investigational
ATC Code J05AF07
DrugBank ID DB14126
KEGG ID D06074
MeSH ID D000068698
PubChem ID 464205
TTD Drug ID D0D9HW
NDC Product Code Not Available
UNII 99YXE507IL
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C9H14N5O4P
CAS Registry Number 147127-20-6
SMILES CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emotional distress19.04.02.0080.158782%Not Available
Lipodystrophy acquired23.07.01.003; 14.08.04.008--Not Available
Homicidal ideation19.05.01.0080.001939%Not Available
Necrotising colitis07.08.01.0130.001939%Not Available
Glomerulonephropathy20.05.03.0050.001939%Not Available
Fanconi syndrome acquired20.05.03.012; 14.01.01.0130.055254%Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Mitochondrial toxicity14.11.02.001; 12.03.01.0090.004847%Not Available
Hepatic cancer metastatic16.07.02.002; 09.04.02.0060.001939%Not Available
Foetal death18.01.02.003; 08.04.01.0110.006786%
Varices oesophageal24.10.02.004; 09.01.06.009; 07.15.05.0010.005816%Not Available
Urine odour abnormal20.02.01.0200.001939%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.006592%Not Available
Chronic hepatic failure09.01.03.0090.001939%Not Available
Metabolic disorder14.11.01.001--Not Available
Ocular icterus09.01.01.007; 06.08.03.009; 01.06.04.0070.001939%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.001--Not Available
Drug resistance08.06.01.0050.039162%Not Available
Urine output increased13.13.03.002--Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Foetal disorder18.03.02.0010.001939%Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Intervertebral disc degeneration15.10.01.0020.001939%Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Sudden hearing loss04.02.01.0090.001939%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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ADReCS-Target
Drug Name ADR Term Target
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