Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Temsirolimus
Drug ID BADD_D02151
Description Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Indications and Usage For the treatment of renal cell carcinoma (RCC). Also investigated for use/treatment in breast cancer, lymphoma (unspecified), rheumatoid arthritis, and multiple myeloma.
Marketing Status Prescription
ATC Code L01EG01
DrugBank ID DB06287
KEGG ID D06068
MeSH ID C401859
PubChem ID 6918289
TTD Drug ID D0ES1Q
NDC Product Code 68254-6237; 0008-1179; 65219-200; 16729-223; 65727-047; 78848-002
Synonyms temsirolimus | rapamycin, 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) | CCI 779 | CCI-779 | Torisel
Chemical Information
Molecular Formula C56H87NO16
CAS Registry Number 162635-04-3
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O) C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin infection23.09.04.002; 11.01.12.003--
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Swelling08.01.03.015--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Venous thrombosis24.01.01.008--Not Available
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
White blood cell count decreased13.01.06.012--
Wound infection12.01.08.012; 11.01.08.010--
Blood phosphorus decreased13.11.01.015--Not Available
Deep vein thrombosis24.01.02.003--Not Available
Lymphatic disorder01.09.01.003--Not Available
Pruritus generalised23.03.12.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Wound complication12.01.08.010--
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Bacterial infection11.02.01.005--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation11.09.01.001; 23.09.05.001--Not Available
Malnutrition14.03.02.004--Not Available
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