Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Temoporfin
Drug ID BADD_D02149
Description Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Foscan.
Indications and Usage For use in the treatment of patients with advanced squamous cell carcinoma of the head and neck failing standard therapies and who are unsuitable for radiotherapy, surgery, or systemic chemotherapy [FDA Label].
Marketing Status Not Available
ATC Code L01XD05
DrugBank ID DB11630
KEGG ID D06066
MeSH ID C072269
PubChem ID 60751
TTD Drug ID D0P5DG
NDC Product Code Not Available
Synonyms temoporfin | m-THPC | mTHPC | meso-tetrahydroxyphenyl chlorin | meso-tetrahydroxyphenylchlorin | 5,10,15,20-tetra(m-hydroxyphenyl)chlorin | meso-tetra-(hydroxyphenyl)chlorin | Foscan | Foslip
Chemical Information
Molecular Formula C44H32N4O4
CAS Registry Number 122341-38-2
SMILES C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7 )O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Blister23.03.01.001; 12.01.06.002--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Constipation07.02.02.001--
Dermatitis bullous23.03.01.002--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysphagia07.01.06.003--
Erythema23.03.06.001--Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Facial pain08.01.08.012--
Fistula15.03.02.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Infection11.01.08.002--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Local swelling08.01.03.013--Not Available
Localised infection11.01.08.006--Not Available
Mouth ulceration07.05.06.004--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Sepsis11.01.11.003--
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