Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telithromycin
Drug ID BADD_D02146
Description Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Indications and Usage For the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
Marketing Status Discontinued
ATC Code J01FA15
DrugBank ID DB00976
KEGG ID D01078
MeSH ID C106791
PubChem ID 3002190
TTD Drug ID D09HNR
NDC Product Code Not Available
Synonyms telithromycin | Ketek | RU 66647 | RU-66647 | HMR 3647 | HMR3647 | HMR-3647
Chemical Information
Molecular Formula C43H65N5O10
CAS Registry Number 191114-48-4
SMILES CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C (=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Candida infection11.03.03.021--
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