Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol
Drug ID BADD_D02115
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D06007
MeSH ID D000077432
PubChem ID 9838022
TTD Drug ID D0K4MH
NDC Product Code Not Available
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H23NO
CAS Registry Number 175591-23-8
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hallucinations, mixed19.10.02.0070.002920%Not Available
Headache17.14.01.0010.051098%
Heart rate decreased13.14.04.0010.004380%Not Available
Heart rate increased13.14.04.0020.010220%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.021899%
Hypersensitivity10.01.03.0030.018979%
Hypersomnia17.15.01.001; 19.02.05.0010.004380%
Hypertension24.08.02.0010.020439%
Hyponatraemia14.05.04.002--
Hypotension24.06.03.0020.020439%
Hypoxia22.02.02.0030.002920%
Ileus07.13.01.0010.010220%
Ileus paralytic07.02.05.0010.004380%Not Available
Incoherent19.10.03.006; 17.02.08.0020.002920%Not Available
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.0100.004380%
Insomnia19.02.01.002; 17.15.03.0020.027739%
Intentional self-injury19.12.01.002; 12.01.08.036--Not Available
Intestinal obstruction07.13.01.0020.002920%Not Available
Irritability08.01.03.011; 19.04.02.0130.013140%
Laryngeal oedema22.04.02.001; 10.01.05.003; 23.04.01.0050.002920%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.016059%
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.002920%Not Available
Liver disorder09.01.08.0010.002920%Not Available
Logorrhoea19.19.02.001; 17.02.08.0060.002920%Not Available
Loss of consciousness17.02.04.0040.018979%Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.003--
Mental impairment19.21.02.003; 17.03.03.0020.002920%Not Available
Middle insomnia19.02.01.003; 17.15.03.0030.002920%Not Available
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