Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Suvorexant
Drug ID BADD_D02103
Description Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Indications and Usage Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Marketing Status Prescription
ATC Code N05CM19
DrugBank ID DB09034
KEGG ID D10082
MeSH ID C551624
PubChem ID 24965990
TTD Drug ID D00OVU
NDC Product Code 0006-0001; 0006-0005; 0006-0335; 0006-0003; 0006-0033; 0006-0004; 50473-0029; 0006-0002; 0006-0325
Synonyms suvorexant | (4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- | MK 4305 | MK4305 | MK-4305 | Belsomra
Chemical Information
Molecular Formula C23H23ClN6O2
CAS Registry Number 1030377-33-3
SMILES CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.001806%Not Available
Abdominal distension07.01.04.0010.000903%
Abnormal dreams19.02.03.001; 17.15.02.0010.012341%Not Available
Aggression19.05.01.0010.000602%Not Available
Agitation19.06.02.001; 17.02.05.0120.001505%
Alanine aminotransferase increased13.03.01.0030.000602%
Altered state of consciousness19.07.01.003; 17.02.04.0010.001806%Not Available
Amnesia19.20.01.001; 17.03.02.0010.002709%
Anxiety19.06.02.0020.005117%
Arrhythmia02.03.02.0010.000602%Not Available
Arthritis15.01.01.0010.001204%
Asthenia08.01.01.001--Not Available
Back disorder15.03.01.0140.000602%Not Available
Blood cholesterol increased13.12.01.002--
Blood glucose decreased13.02.02.0010.000903%Not Available
Blood pressure increased13.14.03.005--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000903%Not Available
Cataplexy19.02.02.003; 17.15.01.003; 15.05.04.0100.000602%Not Available
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.0190.000602%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.001505%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000602%Not Available
Coma17.02.09.0010.001204%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.0050.002107%
Cough22.02.03.001--
Crying17.02.05.013; 12.02.11.001; 08.01.03.005; 19.04.02.0020.000903%Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.0010.003612%
Depressed level of consciousness17.02.04.002--
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