Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status Prescription; Discontinued
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 68071-4215; 23155-019; 70518-1829; 50090-0086; 49964-0018; 43353-495; 63629-5688; 70518-0185; 51927-0054; 51927-0081; 0591-0796; 0013-0101; 59762-0104; 38779-0176; 0013-0102; 50268-730; 59116-0632; 62705-0222; 62991-2704; 57294-021; 59116-0631; 71610-577; 59762-5000; 59116-0633; 59116-0630; 62135-960; 51552-1044; 50090-2013; 49452-7523; 68022-7065; 70518-2342
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Leukopenias NECCytochrome P450 1A2P05177Not Available11600468; 11856081; 11600469
VasculitisMyeloperoxidaseP05164T234717913504; 7913503; 8102951; 7914458; 8624621; 7869327; 7835022; 8095074; 8624617
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis B11.05.06.002; 09.01.09.0030.004835%
Hepatitis cholestatic09.01.01.002--Not Available
Hepatitis fulminant11.07.01.003; 09.01.07.007--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatomegaly09.01.05.0010.002072%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.004835%
Human herpesvirus 6 infection11.05.02.0200.002763%Not Available
Hyperaesthesia17.02.06.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.0030.016578%
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.0080.001382%Not Available
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoprothrombinaemia01.01.01.001--Not Available
Hypothyroidism14.11.01.012; 05.02.03.0010.001382%
Idiopathic pulmonary fibrosis22.01.02.014; 10.02.01.034--Not Available
Immune system disorder10.02.01.001--Not Available
Impetigo23.09.01.006; 11.01.12.0060.002072%Not Available
Infection11.01.08.0020.001982%Not Available
Infectious mononucleosis11.05.10.003; 01.02.01.0070.001382%Not Available
Infertility21.03.02.001--Not Available
Inflammatory bowel disease07.08.01.0160.001382%Not Available
Influenza like illness08.01.03.0100.002763%
Injury corneal12.01.04.018; 06.11.03.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.011052%Not Available
Intestinal obstruction07.13.01.0020.001382%Not Available
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