Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status Prescription; Discontinued
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 68071-4215; 23155-019; 70518-1829; 50090-0086; 49964-0018; 43353-495; 63629-5688; 70518-0185; 51927-0054; 51927-0081; 0591-0796; 0013-0101; 59762-0104; 38779-0176; 0013-0102; 50268-730; 59116-0632; 62705-0222; 62991-2704; 57294-021; 59116-0631; 71610-577; 59762-5000; 59116-0633; 59116-0630; 62135-960; 51552-1044; 50090-2013; 49452-7523; 68022-7065; 70518-2342
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Leukopenias NECCytochrome P450 1A2P05177Not Available11600468; 11856081; 11600469
VasculitisMyeloperoxidaseP05164T234717913504; 7913503; 8102951; 7914458; 8624621; 7869327; 7835022; 8095074; 8624617
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Liver injury12.01.02.003; 09.01.07.0220.004835%Not Available
Oral herpes07.05.07.002; 11.05.02.0050.001382%Not Available
Organising pneumonia22.01.02.0080.001382%Not Available
Oropharyngeal pain07.05.05.004; 22.02.05.0220.004145%
Acute kidney injury20.01.03.016--
Spinal column injury15.02.04.014; 12.01.09.006--Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.001382%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.004145%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.045590%Not Available
Liver function test increased13.03.01.0440.011052%Not Available
Full blood count decreased13.01.07.004--Not Available
Hilar lymphadenopathy22.09.03.005; 01.09.01.0230.001382%Not Available
Parvovirus B19 infection11.05.15.0030.002072%Not Available
Rectal stenosis07.13.05.0030.001382%
Spinal column stenosis15.10.04.003; 17.10.01.0110.001382%Not Available
Anti-neutrophil cytoplasmic antibody positive vasculitis24.05.02.016; 10.02.02.0230.002072%Not Available
Rheumatoid factor increased13.06.01.0190.001382%Not Available
Foetal malformation03.02.01.012; 18.03.02.0160.000901%Not Available
Seronegative arthritis15.01.01.0150.001382%Not Available
Pneumonia cryptococcal11.03.04.005; 22.07.08.0120.001382%Not Available
Inflammatory marker increased13.09.02.0030.004145%Not Available
False negative investigation result13.18.01.0060.002763%Not Available
Spinal pain17.10.01.020; 15.02.01.008; 08.01.08.0300.001382%Not Available
Pseudomyopia06.02.04.0110.001382%Not Available
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