Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sugammadex
Drug ID BADD_D02084
Description Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Indications and Usage Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Marketing Status approved
ATC Code V03AB35
DrugBank ID DB06206
KEGG ID D05940
MeSH ID D000077122
PubChem ID 6918585
TTD Drug ID D08RID
NDC Product Code 58175-0618; 17404-1030; 48087-0151; 60870-0464; 31722-254; 63552-003; 0006-5425; 48087-0153; 0006-5423; 71872-7187; 63552-004; 31722-255
UNII 361LPM2T56
Synonyms Sugammadex | Org 25969 | Sugammadex Sodium | 6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt | Bridion
Chemical Information
Molecular Formula C72H112O48S8
CAS Registry Number 343306-71-8
SMILES C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O) O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC (=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Petechiae23.06.01.003; 01.01.03.002; 24.07.06.0040.001859%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.0030.006443%
Pyrexia08.05.02.003--
Rash erythematous23.03.13.029--Not Available
Red blood cell count decreased13.01.05.007--Not Available
Respiratory arrest22.02.01.0090.003098%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.002478%Not Available
Respiratory distress22.02.01.0120.001239%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001239%
Restlessness19.11.02.002; 17.02.05.021--
Shock24.06.02.0020.003717%Not Available
Sinus tachycardia02.03.03.0100.001239%
Stridor22.04.02.0030.001239%
Subcutaneous emphysema12.02.06.002; 23.07.04.0060.001239%
Supraventricular tachycardia02.03.03.012--
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.003--Not Available
Tachycardia02.03.02.0070.007311%Not Available
Tongue oedema23.04.01.009; 07.14.02.007; 10.01.05.0080.001239%Not Available
Type I hypersensitivity10.01.03.0060.001239%Not Available
Unintended pregnancy18.08.01.0010.001239%Not Available
Unresponsive to stimuli17.02.05.0310.002478%Not Available
Urticaria23.04.02.001; 10.01.06.0010.007559%
Ventricular fibrillation02.03.04.0080.001859%
Ventricular tachycardia02.03.04.0100.001859%
Vomiting07.01.07.003--
Airway complication of anaesthesia12.02.20.001; 22.02.07.006--Not Available
Wound haemorrhage24.07.01.029; 12.01.08.017--Not Available
Haemodynamic instability24.03.02.0060.001859%Not Available
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