Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sufentanil
Drug ID BADD_D02082
Description Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments [L4717]. Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately [L4718]. The sublingual form, manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx), was approved on November 2, 2018 [L4717]. This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural administration [L4717], [A39633].
Indications and Usage Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
Marketing Status Prescription; Discontinued
ATC Code N01AH03
DrugBank ID DB00708
KEGG ID D05938
MeSH ID D017409
PubChem ID 41693
TTD Drug ID D0D8DD
NDC Product Code 0406-0330; 0406-0310; 61621-430; 67651-0327
Synonyms Sufentanil | Sulfentanyl | Sulfentanil | Sufenta | Sufentanil-Ratiopharm | Sufentanil Ratiopharm | SufentanilRatiopharm | Sufentanil Curasan | Curasan, Sufentanil | Sufentanil-Hameln | Sufentanil Hameln | SufentanilHameln | R-30730 | R 30730 | R30730 | Sufentanil Citrate | Citrate, Sufentanil
Chemical Information
Molecular Formula C22H30N2O2S
CAS Registry Number 56030-54-7
SMILES CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute respiratory distress syndrome22.01.03.0010.000206%
Anaemia01.03.02.0010.000788%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.005123%
Anaphylactic shock24.06.02.004; 10.01.07.0020.012610%Not Available
Angioedema23.04.01.001; 10.01.05.0090.001970%Not Available
Anorectal disorder07.03.01.0010.000788%Not Available
Anxiety19.06.02.0020.000788%
Apnoea22.02.01.001--
Arachnoiditis17.06.01.001; 12.02.04.0020.000788%
Arrhythmia02.03.02.001--Not Available
Blood pressure decreased13.14.03.0020.000788%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000788%Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.002759%
Cardiac arrest02.03.04.0010.000411%
Cardiac failure02.05.01.0010.000206%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001182%Not Available
Cauda equina syndrome17.10.01.0010.000308%Not Available
Chills15.05.03.016; 08.01.09.001--
Circulatory collapse24.06.02.0010.000411%Not Available
Coma17.02.09.0010.001182%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.000788%Not Available
Dysgeusia17.02.07.003; 07.14.03.0010.000788%
Dyspnoea22.02.01.004; 02.01.03.0020.001182%
Erythema23.03.06.0010.002364%Not Available
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014--Not Available
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