| Pharmaceutical Information |
| Drug Name |
Strontium chloride sr-89 |
| Drug ID |
BADD_D02075 |
| Description |
Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer.[A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease. It is usually presented mainly in patients with prostatic and breast cancer, as well as in cancer of lung, bladder and thyroid. There has been some cases of apparent tumor regression which has given it a potential tumoricidal effect.[A31263] |
| Indications and Usage |
Strontium-89 Chloride Injection is indicated as a paliative for the relief of bone pain in patients with skeletal metastases. It is impotant to confirm the presence of bone metastases prior the beginning of therapy.[A31264] |
| Marketing Status |
Prescription |
| ATC Code |
V10BX01 |
| DrugBank ID |
DB09498
|
| KEGG ID |
D02006
|
| MeSH ID |
C025700
|
| PubChem ID |
5388879
|
| TTD Drug ID |
D0R6HN
|
| NDC Product Code |
72928-089 |
| Synonyms |
strontium chloride | strontium chloride hexahydrate | strontium chloride, disodium salt | strontium chloride, 85Sr-labeled | strontium chloride Sr 85 | strontium chloride, 89Sr-labeled | strontium chloride Sr 89 | strontium-89 chloride | strontium chloride, 90Sr-labeled | Metastron | strontium chloride monohydrate |
|
| Chemical Information |
| Molecular Formula |
Cl2Sr |
| CAS Registry Number |
38270-90-5 |
| SMILES |
[Cl-].[Cl-].[Sr+2] |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Bone pain | 15.02.01.001 | - | - | | | Chills | 15.05.03.016; 08.01.09.001 | - | - | | | Death | 08.04.01.001 | - | - | | | Leukopenia | 01.02.02.001 | - | - | Not Available | | Pyrexia | 08.05.02.003 | - | - | | | Sepsis | 11.01.11.003 | - | - | | | Bone marrow toxicity | 12.03.01.006; 01.03.03.004 | - | - | Not Available | | Hot flush | 21.02.02.001; 08.01.03.027; 24.03.01.005 | - | - | |
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