Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Spironolactone
Drug ID BADD_D02066
Description Spironolactone is a potassium sparing diuretic like [eplerenone] that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention.[A11837]. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837,A178246] It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.[Label] Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135] Spironolactone is also frequently used in medical gender transition.[A178138] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243,L6187]
Indications and Usage Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
Marketing Status Prescription; Discontinued
ATC Code C03DA01
DrugBank ID DB00421
KEGG ID D00443
MeSH ID D013148
PubChem ID 5833
TTD Drug ID D0EP0C
NDC Product Code 63629-1062; 70518-1746; 71335-0966; 68382-661; 59651-426; 63629-5341; 68071-4374; 71205-146; 63629-2437; 70518-2384; 68071-2606; 50090-3916; 70518-1742; 65162-511; 63187-841; 51079-980; 50090-1292; 0025-1031; 71335-0053; 63629-1095; 55525-0002; 70518-0563; 71335-0304; 55700-934; 38779-0096; 63629-1065; 67296-1692; 67296-1403; 63629-2436; 59746-218; 49452-7220; 70518-2588; 0378-0243; 63187-861; 53489-329; 70518-0455; 67544-310; 59746-216; 0378-2146; 55700-713; 51079-103; 59651-427; 51655-344; 70518-2385; 71335-1546; 16714-084; 76420-062; 63629-2438; 63629-1061; 69584-852; 63629-8539; 43063-832; 16729-227; 70518-1314; 70518-3118; 16729-226; 0904-6927; 70771-1027; 70934-367; 68788-7019; 63629-4094; 53002-1707; 71205-147; 82298-121; 63629-1066; 68382-662; 68788-7297; 42708-126; 63629-1094; 51079-979; 53002-4720; 68788-7051; 71610-287; 55154-1495; 70771-1029; 55700-953; 69584-854; 63187-634; 16637-0020; 0378-0437; 0615-8178; 53746-514; 53746-515; 63629-1064; 60687-487; 70518-1334; 43063-974; 63629-1092; 0615-8221; 16714-086; 51552-0276; 63629-1093; 65162-515; 0025-1001; 59746-217; 70518-2589; 63739-545; 71335-1604; 63739-544; 70518-2386; 70518-0603; 70771-1028; 43063-835; 76420-063; 67296-1100; 0025-1041; 69584-853; 79572-032; 70966-0028; 42708-101; 16714-085; 50090-3580; 54348-340; 53489-143; 71335-0401; 68382-660; 71610-288; 16729-225; 50090-1308; 60687-476; 70518-2461; 71205-148; 57582-030; 61907-031; 65162-514; 55154-5517; 72189-329; 63629-1067; 46438-0033; 53746-511; 50090-3747; 61919-772; 55154-3556; 59651-428; 71335-1586; 45541-1134; 51927-1377; 53489-328; 70518-2585; 60687-465; 63629-1830; 71610-102
Synonyms Spironolactone | Spirolactone | Veroshpiron | Verospirone | Spiractin | Spirobeta | Spirogamma | Spirolang | Spirono-Isis | Spirono Isis | Spironone | Spirospare | Aldactone | Verospiron | Aldactone A | Aquareduct | Duraspiron | Espironolactona Alter | Espironolactona Mundogen | Flumach | Frumikal | Jenaspiron | Novo-Spiroton | Novo Spiroton | NovoSpiroton | Practon | SC-9420 | SC 9420 | SC9420 | Spiro L.U.T. | Spiro Von Ct | Ct, Spiro Von | Von Ct, Spiro
Chemical Information
Molecular Formula C24H32O4S
CAS Registry Number 52-01-7
SMILES CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000605%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.000692%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.0020.000519%
Atrioventricular block02.03.01.0020.000346%Not Available
Atrioventricular block first degree02.03.01.0040.000173%
Atrioventricular block second degree02.03.01.0050.000173%
Back pain15.03.04.005--
Benign breast neoplasm21.05.01.009; 16.14.01.005--Not Available
Blister23.03.01.001; 12.01.06.0020.000432%Not Available
Blood bilirubin increased13.03.01.0080.000432%
Blood creatine increased13.13.01.0010.000173%Not Available
Blood creatine phosphokinase increased13.04.01.0010.000259%
Blood creatinine increased13.13.01.0040.001124%
Blood glucose increased13.02.02.002--Not Available
Blood potassium decreased13.11.01.0100.000259%Not Available
Blood potassium increased13.11.01.0110.001211%Not Available
Blood pressure decreased13.14.03.0020.000346%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.0070.000259%Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.000259%Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.000173%
Blood urea increased13.13.01.0060.000519%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.001902%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.000173%Not Available
Breast enlargement21.05.04.001--Not Available
Breast pain21.05.05.0030.000605%
Breast tenderness21.05.05.0040.000865%Not Available
The 2th Page    First    Pre   2 3 4 5 6    Next   Last    Total 13 Pages