Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sodium thiosulfate
Drug ID BADD_D02051
Description Thiosulfuric acid (as sodium thiosulfate) has the chemical name thiosulfuric acid, disodium salt, pentahydrate. The chemical formula is Na2S2O3•5H2O and the molecular weight is 248.17. Sodium Thiosulfate Injection is a cyanide antidote which contains one 50 mL glass vial containing a 25% solution of Sodium Thiosulfate Injection. It has been indicated as antidote for cyanide poisoning. It is also used as adjunct agent for patients taking cisplatin chemotherapy. Beside the above indications, sodium thiosulfate could be used as ingredient in the following: agricultural chemicals (non-pesticidal), fillers, intermediates, laboratory chemicals, oxidizing/reducing agents, process regulators, processing aids, and solids separation agents.
Indications and Usage Antineoplastic adjunct:
Marketing Status Prescription; Discontinued
ATC Code V03AB06
DrugBank ID DB09499
KEGG ID D01091
MeSH ID C017717
PubChem ID 24477
TTD Drug ID D0P9NT
NDC Product Code 60267-705; 17156-946; 73435-013; 51552-1421; 49574-629; 49574-518
Synonyms sodium thiosulfate | thiosulfuric acid, disodium salt | sodium thiosulfate pentahydrate | sodium thiosulfate (USAN) | pentahydrate of sodium thiosulfate | sodium thiosulfate anhydrous
Chemical Information
Molecular Formula Na2O3S2
CAS Registry Number 7772-98-7
SMILES [O-]S(=O)(=S)[O-].[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Arthralgia15.01.02.001--
Delusion19.10.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Hallucination19.10.02.002--
Hyperreflexia17.02.01.002--Not Available
Hypotension24.06.03.002--
Muscle spasms15.05.03.004--
Ototoxicity12.03.01.012; 04.03.01.004--Not Available
Polyuria20.02.03.002--Not Available
Psychotic behaviour19.03.01.003--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Vision blurred17.17.01.010; 06.02.06.007--
Musculoskeletal discomfort15.03.04.001--Not Available
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