Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sodium bicarbonate
Drug ID BADD_D02034
Description Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Indications and Usage Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
Marketing Status approved
ATC Code B05CB04; B05XA02
DrugBank ID DB01390
KEGG ID D01203
MeSH ID D017693
PubChem ID 516892
TTD Drug ID D02FLB
NDC Product Code 77333-827; 10237-595; 49452-6611; 10135-684; 10135-685; 70491-105; 51662-1400; 55681-307; 63323-083; 82645-904; 90107-1103; 52946-0929; 24286-1523; 24286-1537; 54738-020; 63629-8775; 64980-528; 0395-2685; 70369-002; 70795-1180; 72572-740; 10237-593; 49452-6610; 52682-206; 63323-089; 0409-6625; 0409-6637; 70795-1130; 71872-7247; 69367-258; 76328-223; 76329-3352; 10237-594; 10237-598; 83094-102; 51662-1383; 51754-5002; 51754-5012; 52584-096; 0409-4900; 0409-5555; 71610-438; 76328-221; 77333-831; 51754-5001; 51754-5011; 54738-035; 0409-4916; 70795-1190; 0802-2685; 90107-1280; 10106-3509; 10237-590; 10237-592; 51552-0059; 58989-001; 43353-041; 43353-162; 53145-300; 0404-9951; 0404-9980; 70369-001; 0536-1046; 0536-1047; 71610-669; 71872-7097; 24689-137; 51662-1255; 55758-319; 64980-294; 0404-9985; 71872-7266; 81665-200; 10095-100; 70491-102; 44224-1040; 52584-099; 0409-5534; 90107-1030; 10237-596; 10237-597; 0904-7261; 10237-591; 71901-604; 0404-9950; 0404-9984; 83094-105; 51662-1497; 51662-1573; 55681-331; 57896-676
UNII 8MDF5V39QO
Synonyms Sodium Bicarbonate | Bicarbonate, Sodium | Carbonic Acid Monosodium Salt | Sodium Hydrogen Carbonate | Hydrogen Carbonate, Sodium | Baking Soda | Soda, Baking
Chemical Information
Molecular Formula NaHCO3
CAS Registry Number 144-55-8
SMILES C(=O)(O)[O-].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypokalaemia14.05.03.0020.001281%
Hypotension24.06.03.0020.000854%
Injection site erythema23.03.06.015; 12.07.03.001; 08.02.03.0010.004270%Not Available
Injection site induration12.07.03.007; 08.02.03.0070.001452%Not Available
Injection site pain12.07.03.011; 08.02.03.0100.008412%Not Available
Injection site urticaria12.07.03.029; 10.01.06.003; 08.02.03.029; 23.04.02.0030.002178%Not Available
Lactic acidosis14.01.01.0020.000427%Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.0030.000854%
Metabolic acidosis14.01.01.0030.001068%Not Available
Metabolic alkalosis14.01.02.0040.000427%Not Available
Muscle rigidity15.05.04.001; 17.05.02.0050.000427%Not Available
Myalgia15.05.02.0010.000854%
Neck pain15.03.04.0090.000939%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Pain08.01.08.0040.005508%
Pain in extremity15.03.04.0100.001452%
Pyrexia08.05.02.0030.001879%
Respiratory depression22.02.01.010; 17.02.05.0470.000427%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000427%
Rhabdomyolysis15.05.05.0020.000641%
Seizure17.12.03.0010.000854%
Skin fragility23.03.03.0090.000427%Not Available
Somnolence19.02.05.003; 17.02.04.006--
Ulcer08.03.06.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular tachycardia02.03.04.0100.000427%
Vomiting07.01.07.0030.001153%
General physical health deterioration08.01.03.0180.000427%Not Available
Haemodynamic instability24.03.02.0060.000427%Not Available
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