Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevoflurane
Drug ID BADD_D02015
Description Sevoflurane, also called fluoromethyl, is an ether inhalation anaesthetic agent used for the induction and maintenance of general anesthesia. It is a volatile, non-flammable, non-irritant, and easy-to-administer compound with a low solubility profile and blood-to-gas partition coefficient.
Indications and Usage Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Marketing Status Prescription
ATC Code N01AB08
DrugBank ID DB01236
KEGG ID D00547
MeSH ID D000077149
PubChem ID 5206
TTD Drug ID D0W6ZF
NDC Product Code 0074-4456; 10019-651; 0781-6160; 12164-005; 66794-015; 66794-022; 54122-4486; 10019-653; 42677-110; 66794-012; 57884-0036; 12164-009
Synonyms Sevoflurane | Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl Ether | Fluoromethyl Hexafluoroisopropyl Ether | Sevorane | Ultane | BAX 3084
Chemical Information
Molecular Formula C4H3F7O
CAS Registry Number 28523-86-6
SMILES C(OC(C(F)(F)F)C(F)(F)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cognitive disorderGlycine receptor subunit alpha-1P23415T5026925774088
Cognitive disorderApoptosis regulator BAXQ07812T8925125774088
Cognitive disorderApoptosis regulator Bcl-2P10415T3130925774088
Cognitive disorderCaspase-3P42574T5794325774088
Nerve injuryGlycine receptor subunit alpha-1P23415T5026925774088
Nerve injuryApoptosis regulator Bcl-2P49950Not Available25774088
Nerve injuryCaspase-3P42574T5794325774088
Nerve injuryApoptosis regulator BAXQ07812T8925125774088
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure decreased13.14.03.0020.003153%Not Available
Blood urea13.13.01.019--Not Available
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.0010.000788%Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.0020.001970%Not Available
Breath holding22.02.01.016; 19.01.01.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.002364%
Cardiac arrest02.03.04.0010.000720%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills15.05.03.016; 08.01.09.0010.003153%
Chromaturia20.02.01.0020.000788%
Coagulopathy01.01.02.0010.002364%Not Available
Coma17.02.09.0010.002364%Not Available
Confusional state19.13.01.001; 17.02.03.0050.001576%
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Death08.04.01.001--
Delayed recovery from anaesthesia17.02.04.011; 12.02.12.0030.001970%Not Available
Delirium19.13.02.0010.001182%
Depressed level of consciousness17.02.04.0020.001182%
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.010--Not Available
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.0010.000788%
Dysgeusia07.14.03.001; 17.02.07.003--
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