Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline hydrochloride
Drug ID BADD_D02011
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D00825
MeSH ID D020280
PubChem ID 63009
TTD Drug ID D0K0TC
NDC Product Code 16714-612; 55700-340; 43602-979; 53869-4900; 0049-4960; 68071-4029; 71093-129; 65841-044; 65841-043; 50090-2080; 72865-205; 45865-518; 59762-0067; 71205-343; 65015-821; 43602-980; 61919-345; 46144-108; 55700-910; 68071-3071; 53002-3192; 70518-0094; 0049-4900; 65862-013; 70518-1350; 63187-859; 72789-088; 68071-4658; 65977-0056; 68071-3146; 64980-409; 61919-014; 43353-970; 53002-1507; 50090-3203; 68071-4993; 68788-8109; 71205-028; 31722-147; 43063-855; 65841-045; 51655-265; 68071-1911; 60760-737; 71205-455; 71205-205; 68071-4973; 53104-7590; 50436-0217; 53808-1127; 65862-222; 50090-2976; 50436-0216; 16729-216; 60687-242; 53002-1192; 70518-3145; 43353-447; 68071-2496; 67046-559; 55700-948; 65862-011; 60760-738; 51655-345; 71610-433; 68788-6429; 68788-7928; 72189-122; 60687-253; 65862-012; 61919-086; 42708-124; 71610-106; 53002-4215; 43063-033; 71093-143; 51655-173; 63629-8774; 63629-8127; 70934-192; 71335-0328; 60760-091; 69097-833; 71335-0210; 65977-0002; 53002-3215; 65862-224; 68071-4462; 55700-362; 71335-0415; 72865-206; 68071-3309; 55289-409; 50090-3945; 31722-146; 71093-130; 67046-554; 50090-3153; 71335-0808; 53869-4960; 68071-1318; 55154-4687; 58118-0834; 53002-2507; 55154-4692; 62350-0043; 70934-190; 71610-435; 71335-0403; 53104-7578; 16729-217; 43063-754; 68071-4370; 70518-1748; 16714-613; 68788-6835; 72789-013; 70518-2448; 70934-169; 71093-131; 0049-4910; 70518-1913; 68645-521; 69097-834; 72865-207; 53869-4910; 63187-795; 31722-145; 60760-612; 43602-981; 16714-601; 71205-047; 50090-2609; 71335-1078; 77777-108; 71335-0718; 16729-215; 52427-672; 68071-1317; 71335-0510; 0143-9655; 70518-2812; 68788-6437; 0049-0050; 68071-4750; 50090-3947; 69097-835; 63187-767; 60687-231; 50436-0215; 71335-0896; 42708-092; 55111-968; 70518-2706; 53002-1215; 72789-092; 52427-664; 16714-611; 68645-523; 55700-562; 68071-4494; 68645-522
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H18Cl3N
CAS Registry Number 79559-97-0
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Menstruation irregular21.01.01.005; 05.05.01.008--
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Metrorrhagia21.01.01.006--Not Available
Micturition disorder20.02.02.005--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Monoparesis17.01.04.011--Not Available
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Movement disorder17.01.02.010--Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myoclonus17.02.05.008--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neuroleptic malignant syndrome08.05.01.005; 17.05.02.003; 15.05.04.015; 12.03.01.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurosis19.06.01.001--Not Available
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