Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline hydrochloride
Drug ID BADD_D02011
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D00825
MeSH ID D020280
PubChem ID 63009
TTD Drug ID D0K0TC
NDC Product Code 16714-612; 55700-340; 43602-979; 53869-4900; 0049-4960; 68071-4029; 71093-129; 65841-044; 65841-043; 50090-2080; 72865-205; 45865-518; 59762-0067; 71205-343; 65015-821; 43602-980; 61919-345; 46144-108; 55700-910; 68071-3071; 53002-3192; 70518-0094; 0049-4900; 65862-013; 70518-1350; 63187-859; 72789-088; 68071-4658; 65977-0056; 68071-3146; 64980-409; 61919-014; 43353-970; 53002-1507; 50090-3203; 68071-4993; 68788-8109; 71205-028; 31722-147; 43063-855; 65841-045; 51655-265; 68071-1911; 60760-737; 71205-455; 71205-205; 68071-4973; 53104-7590; 50436-0217; 53808-1127; 65862-222; 50090-2976; 50436-0216; 16729-216; 60687-242; 53002-1192; 70518-3145; 43353-447; 68071-2496; 67046-559; 55700-948; 65862-011; 60760-738; 51655-345; 71610-433; 68788-6429; 68788-7928; 72189-122; 60687-253; 65862-012; 61919-086; 42708-124; 71610-106; 53002-4215; 43063-033; 71093-143; 51655-173; 63629-8774; 63629-8127; 70934-192; 71335-0328; 60760-091; 69097-833; 71335-0210; 65977-0002; 53002-3215; 65862-224; 68071-4462; 55700-362; 71335-0415; 72865-206; 68071-3309; 55289-409; 50090-3945; 31722-146; 71093-130; 67046-554; 50090-3153; 71335-0808; 53869-4960; 68071-1318; 55154-4687; 58118-0834; 53002-2507; 55154-4692; 62350-0043; 70934-190; 71610-435; 71335-0403; 53104-7578; 16729-217; 43063-754; 68071-4370; 70518-1748; 16714-613; 68788-6835; 72789-013; 70518-2448; 70934-169; 71093-131; 0049-4910; 70518-1913; 68645-521; 69097-834; 72865-207; 53869-4910; 63187-795; 31722-145; 60760-612; 43602-981; 16714-601; 71205-047; 50090-2609; 71335-1078; 77777-108; 71335-0718; 16729-215; 52427-672; 68071-1317; 71335-0510; 0143-9655; 70518-2812; 68788-6437; 0049-0050; 68071-4750; 50090-3947; 69097-835; 63187-767; 60687-231; 50436-0215; 71335-0896; 42708-092; 55111-968; 70518-2706; 53002-1215; 72789-092; 52427-664; 16714-611; 68645-523; 55700-562; 68071-4494; 68645-522
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H18Cl3N
CAS Registry Number 79559-97-0
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.001--Not Available
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Ear pain04.03.01.003--
Eczema23.03.04.006--
Ejaculation delayed21.03.01.001--Not Available
Ejaculation disorder21.03.01.002--
Ejaculation failure21.03.01.003--Not Available
Electric shock12.01.08.032--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Endocrine disorder05.09.01.001--Not Available
Enuresis20.02.02.003; 19.07.04.001--Not Available
Enzyme abnormality14.11.01.015--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Erythema23.03.06.001--Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Euphoric mood19.04.02.006--
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001--Not Available
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