Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 0904-6925; 68180-352; 63187-478; 70518-2512; 0904-6924; 70518-1461; 70518-1040; 70518-0153; 0904-6926; 50090-3562; 43353-817; 68180-353; 50090-5848; 43353-809; 0615-7990; 67296-1199; 63187-055; 0615-7989; 71335-0404; 68645-589; 70518-0378; 50090-0989; 0615-7991; 68180-351; 68788-7329; 63187-212; 68071-4400; 76282-212; 76282-213; 70518-1617; 65427-009; 76282-214
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast discharge21.05.05.0010.000121%Not Available
Breast enlargement21.05.04.0010.000060%Not Available
Breast pain21.05.05.0030.000151%
Breath odour07.01.06.0020.000060%Not Available
Breech presentation18.03.04.0010.000091%Not Available
Bronchiolitis22.03.02.004; 11.05.04.0080.000091%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchopulmonary dysplasia22.11.01.001; 18.04.10.0010.000047%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bruxism19.11.03.001; 07.01.06.0080.001693%Not Available
Bundle branch block right02.03.01.0110.000060%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.007--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.0010.000544%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.0010.000134%Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Carpal tunnel syndrome17.09.02.0010.000181%Not Available
Cataract06.06.01.001--
Catatonia19.11.01.0010.000332%Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebellar syndrome17.02.02.0020.000060%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction17.08.01.004; 24.04.06.002--Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.000121%
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