Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 0904-6925; 68180-352; 63187-478; 70518-2512; 0904-6924; 70518-1461; 70518-1040; 70518-0153; 0904-6926; 50090-3562; 43353-817; 68180-353; 50090-5848; 43353-809; 0615-7990; 67296-1199; 63187-055; 0615-7989; 71335-0404; 68645-589; 70518-0378; 50090-0989; 0615-7991; 68180-351; 68788-7329; 63187-212; 68071-4400; 76282-212; 76282-213; 70518-1617; 65427-009; 76282-214
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Naevus flammeus24.03.03.036; 23.05.01.016; 03.05.01.0200.000151%Not Available
Right atrial dilatation02.04.02.0320.000151%Not Available
Left atrial dilatation02.04.02.0250.000121%Not Available
Skin plaque23.03.03.0440.000060%Not Available
Reflux laryngitis22.04.01.0070.000151%Not Available
Congenital tricuspid valve incompetence03.07.05.012; 02.07.05.0030.000181%Not Available
Facial asymmetry15.10.05.0040.000060%Not Available
Overconfidence19.05.01.0200.000060%Not Available
Subretinal fluid12.01.04.031; 06.09.03.0270.000060%Not Available
Coma scale abnormal13.07.03.0120.000060%Not Available
Streptococcus test positive13.08.01.0160.000060%Not Available
Herbal interaction08.06.03.0050.000181%Not Available
Huntington's disease03.10.01.009; 17.01.01.0050.000091%Not Available
Limb asymmetry15.10.03.0090.000060%
Psychological trauma19.01.02.0170.000060%Not Available
Glucocorticoid deficiency05.01.02.011; 14.11.01.0370.000121%Not Available
Foetal placental thrombosis24.01.05.009; 18.05.02.0020.000363%Not Available
Neonatal behavioural syndrome22.11.02.007; 18.04.04.010; 17.02.05.058; 15.05.04.0200.000484%Not Available
Congenital skin dimples03.05.01.017; 23.07.05.0060.000121%Not Available
Genital paraesthesia17.02.06.032; 21.10.05.0160.000060%Not Available
Autoscopy19.10.02.012; 17.02.03.0150.000060%Not Available
Alveolar bone resorption15.02.03.013; 07.09.05.0100.000060%Not Available
Poor feeding infant18.04.06.006; 14.03.02.0220.000212%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000091%Not Available
Meconium aspiration syndrome22.11.01.007; 18.04.10.0020.000060%Not Available
Hemianaesthesia17.02.07.0210.000060%Not Available
Infantile apnoea22.11.02.004; 18.04.15.0030.000665%Not Available
Selective eating disorder19.09.01.012; 14.03.02.0240.000272%Not Available
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