Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Morose19.04.02.0180.000038%Not Available
Neglect of personal appearance19.01.02.0150.000013%Not Available
Neonatal anoxia22.11.02.005; 18.04.15.0040.000038%Not Available
Neonatal asphyxia22.11.02.006; 18.04.15.0050.000038%Not Available
Neonatal respiratory arrest22.11.02.008; 18.04.17.0010.000038%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.000337%Not Available
Neonatal respiratory failure22.11.02.011; 18.04.17.0030.000013%Not Available
Normal newborn18.08.06.0010.000034%Not Available
Oesophageal ulcer haemorrhage24.07.02.051; 07.04.05.0070.000032%Not Available
Overweight14.03.02.0210.000041%Not Available
Persecutory delusion19.10.01.0070.000115%Not Available
Placental insufficiency24.04.12.002; 18.05.02.0060.000032%Not Available
Post-traumatic stress disorder19.06.06.0020.000019%Not Available
Poverty of speech19.19.02.007; 17.02.08.0200.000019%Not Available
Pulmonary artery stenosis24.04.09.011; 22.06.03.0060.000032%Not Available
Pulmonary valve stenosis02.07.04.0050.000064%Not Available
Rash papulosquamous23.03.08.0140.000013%Not Available
Reading disorder19.21.05.0030.000013%Not Available
Small for dates baby18.04.02.0020.000446%Not Available
Social anxiety disorder19.06.03.0100.000034%Not Available
Speech disorder developmental19.19.01.003; 17.02.08.0110.000076%Not Available
Threatened labour18.07.01.0090.000038%Not Available
Transient tachypnoea of the newborn22.11.01.010; 18.04.09.0100.000057%Not Available
Tremor neonatal18.04.04.012; 17.01.06.0100.000057%Not Available
Violence-related symptom19.05.01.0220.000032%Not Available
Umbilical cord abnormality18.04.14.0030.000019%Not Available
Hypertonia neonatal18.04.01.016; 17.05.02.017; 15.05.04.0190.000089%Not Available
Cerebral ventricle dilatation17.11.01.0130.000025%Not Available
Neonatal hypotension24.06.03.014; 18.04.07.0080.000013%Not Available
Hypothermia neonatal18.04.06.004; 12.05.03.002; 08.05.01.0070.000019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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