Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 0904-6925; 68180-352; 63187-478; 70518-2512; 0904-6924; 70518-1461; 70518-1040; 70518-0153; 0904-6926; 50090-3562; 43353-817; 68180-353; 50090-5848; 43353-809; 0615-7990; 67296-1199; 63187-055; 0615-7989; 71335-0404; 68645-589; 70518-0378; 50090-0989; 0615-7991; 68180-351; 68788-7329; 63187-212; 68071-4400; 76282-212; 76282-213; 70518-1617; 65427-009; 76282-214
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.001--
Areflexia17.02.01.0010.000181%Not Available
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arteriosclerosis24.04.02.001--Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000032%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.0110.000047%Not Available
Aspiration22.02.07.007--
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.0020.000393%Not Available
Asthma22.03.01.002; 10.01.03.0100.000423%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.0010.000091%
Atrial fibrillation02.03.03.002--
Atrial septal defect02.04.02.009; 03.07.02.0020.000828%Not Available
Atrial tachycardia02.03.03.0040.000060%
Atrioventricular block02.03.01.002--Not Available
Atrophic vulvovaginitis21.02.01.003--Not Available
Attention deficit/hyperactivity disorder19.21.04.0010.000363%Not Available
Autism19.22.02.001; 17.03.05.0010.000212%Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Benign intracranial hypertension17.07.02.0010.000121%Not Available
Biliary colic09.02.01.0010.000060%Not Available
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