Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neurological symptom17.02.05.0100.000108%Not Available
Freezing phenomenon17.01.05.0060.000013%Not Available
Arterial disorder24.03.02.0200.000038%Not Available
Cranial nerve disorder17.04.01.0010.000025%Not Available
Eye movement disorder17.02.05.025; 06.05.02.0080.000096%Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.000051%Not Available
Gastrointestinal motility disorder07.02.03.0010.000057%Not Available
Impulse-control disorder19.18.01.0020.000034%Not Available
Limb discomfort15.03.04.014--Not Available
Jaw disorder15.02.04.0090.000019%Not Available
Learning disorder19.21.05.0010.000025%Not Available
Mental disorder19.07.01.0020.000308%Not Available
Motor dysfunction15.05.06.006; 17.01.02.0310.000089%Not Available
Spinal disorder15.02.04.0230.000019%Not Available
Temperature regulation disorder05.03.04.013; 08.05.01.0040.000025%Not Available
Therapeutic reaction time decreased08.06.01.015--Not Available
Abnormal behaviour19.01.01.0010.000483%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.001046%
Feeling of body temperature change08.01.09.0120.000045%Not Available
Erectile dysfunction21.03.01.007; 19.08.04.0010.000381%
Psychiatric symptom19.01.02.0010.000097%Not Available
Respiratory disorder neonatal22.11.01.002; 18.04.09.0020.000248%Not Available
Inner ear disorder04.04.02.002--Not Available
Parkinson's disease17.01.05.0100.000070%Not Available
Sensation of foreign body08.01.09.0020.000085%Not Available
Adjustment disorder19.23.01.0010.000019%Not Available
Disease recurrence08.01.03.0500.000409%Not Available
Neoplasm recurrence16.16.02.0040.000051%Not Available
Obstructive airways disorder22.03.01.0110.000045%Not Available
Psychotic disorder19.03.01.0020.000306%
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ADReCS-Target
Drug Name ADR Term Target
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