Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Saxagliptin hydrochloride
Drug ID BADD_D01993
Description Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Indications and Usage Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
Marketing Status Prescription
ATC Code A10BH03
DrugBank ID DB06335
KEGG ID D10262
MeSH ID C502994
PubChem ID 49800073
TTD Drug ID D0Y6QC
NDC Product Code 62756-209; 50370-0039; 55111-960
Synonyms saxagliptin | 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate | Onglyza | BMS 477118 | BMS477118 | BMS-477118
Chemical Information
Molecular Formula C18H26ClN3O2
CAS Registry Number 709031-78-7
SMILES C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cardiac failureDipeptidyl peptidase 4P27487T31391Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Headache17.14.01.001--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Infection11.01.08.002--Not Available
Lymphocyte count decreased13.01.06.006--
Lymphopenia01.02.02.002--Not Available
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Rash23.03.13.001--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Thrombocytopenia01.08.01.002--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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