Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Saxagliptin
Drug ID BADD_D01992
Description Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Indications and Usage Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
Marketing Status approved
ATC Code A10BH03
DrugBank ID DB06335
KEGG ID D08996
MeSH ID C502994
PubChem ID 11235729
TTD Drug ID D0K9MY
NDC Product Code 50193-4212; 0310-6100; 0310-6105; 11722-078; 0310-7100; 50370-0030; 55154-6931; 0310-7105
UNII 9GB927LAJW
Synonyms saxagliptin | 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate | Onglyza | BMS 477118 | BMS477118 | BMS-477118
Chemical Information
Molecular Formula C18H25N3O2
CAS Registry Number 361442-04-8
SMILES C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000720%
Abdominal pain07.01.05.0020.001539%
Abdominal pain upper07.01.05.0030.001211%
Acidosis14.01.03.0020.000327%
Acute abdomen07.01.06.0150.000327%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000655%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000491%Not Available
Arrhythmia02.03.02.0010.001048%Not Available
Arthralgia15.01.02.0010.004059%
Asthenia08.01.01.0010.000982%Not Available
Back pain15.03.04.0050.000884%
Bladder cancer20.03.04.001; 16.08.01.0010.000655%Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood triglycerides increased13.12.03.001--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.000327%Not Available
Cardiac failure02.05.01.0010.002946%
Cardiac failure acute02.05.01.0050.000327%Not Available
Cardiac failure congestive02.05.01.0020.000982%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.001146%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000655%
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000491%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.000655%Not Available
Chills15.05.03.016; 08.01.09.0010.000327%
Cholecystitis09.03.01.0010.000327%
Cholelithiasis09.03.01.0020.001048%Not Available
Circulatory collapse24.06.02.0010.000327%Not Available
Constipation07.02.02.0010.001048%
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ADReCS-Target
Drug Name ADR Term Target
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