Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol xinafoate
Drug ID BADD_D01982
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Marketing Status Prescription; Discontinued
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D00687
MeSH ID D000068299
PubChem ID 56801
TTD Drug ID D0L5YV
NDC Product Code 14501-0045; 63190-0650; 52482-002; 50909-4102; 0173-0521; 58032-0143; 53104-7541; 64567-0007; 52221-109; 15308-1021; 55018-402
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C36H45NO7
CAS Registry Number 94749-08-3
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T52522Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Pallor23.03.03.031; 08.01.03.032; 24.03.04.001--Not Available
Paraesthesia17.02.06.005--
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Pharyngitis11.01.13.003; 22.07.03.004; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sinus congestion22.04.06.001--Not Available
Sinus headache22.02.05.023; 17.14.01.002--
Sinusitis11.01.13.005; 22.07.03.007--
Sleep disorder19.02.04.001--Not Available
Stridor22.04.02.003--
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015--Not Available
Throat irritation22.02.05.013; 07.05.03.004--Not Available
Tracheitis11.01.13.007; 22.07.03.009--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Musculoskeletal disorder15.03.01.004--Not Available
Muscle tightness15.05.03.007--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Dental discomfort07.09.06.002--Not Available
The 2th Page    First    Pre   2 3    Next   Last    Total 3 Pages