Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine hydrochloride
Drug ID BADD_D01968
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Prescription; Discontinued
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D04048
MeSH ID D000077212
PubChem ID 175804
TTD Drug ID D09RHQ
NDC Product Code 70069-063; 43066-015; 0409-9300; 65145-108; 43066-023; 55150-201; 63323-285; 55150-196; 63323-286; 55150-195; 46014-1058; 25021-671; 0409-9301; 65145-109; 63323-287; 55150-198; 70518-2681; 63323-288; 49386-025; 55150-199; 65145-107; 48954-722; 0143-9265; 67184-0022; 25021-652; 0143-9263; 70069-061; 55150-197; 76339-124; 0404-9924; 70069-064; 17478-081; 43066-019; 51552-1590; 70516-0165; 0143-9264; 0409-9302; 49452-6303; 0143-9266; 52584-286; 43066-027; 65372-1159; 70069-062; 17478-082; 65145-110; 0409-9303; 61876-0071; 55150-200; 70069-065; 70069-066; 70069-067
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H27ClN2O
CAS Registry Number 98717-15-8
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body temperature decreased13.15.01.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bradycardia foetal18.03.02.006; 02.03.02.018--Not Available
Breast feeding26.05.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Carbon dioxide increased13.02.01.011--Not Available
Cardiac arrest02.03.04.001--
Cardiac output decreased13.14.02.001--Not Available
Cauda equina syndrome17.10.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysarthria19.19.03.001; 17.02.08.001--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram ST segment13.14.05.035--Not Available
Electrocardiogram ST segment abnormal13.14.05.017--Not Available
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