Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine hydrochloride
Drug ID BADD_D01968
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Prescription; Discontinued
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D04048
MeSH ID D000077212
PubChem ID 175804
TTD Drug ID D09RHQ
NDC Product Code 70069-063; 43066-015; 0409-9300; 65145-108; 43066-023; 55150-201; 63323-285; 55150-196; 63323-286; 55150-195; 46014-1058; 25021-671; 0409-9301; 65145-109; 63323-287; 55150-198; 70518-2681; 63323-288; 49386-025; 55150-199; 65145-107; 48954-722; 0143-9265; 67184-0022; 25021-652; 0143-9263; 70069-061; 55150-197; 76339-124; 0404-9924; 70069-064; 17478-081; 43066-019; 51552-1590; 70516-0165; 0143-9264; 0409-9302; 49452-6303; 0143-9266; 52584-286; 43066-027; 65372-1159; 70069-062; 17478-082; 65145-110; 0409-9303; 61876-0071; 55150-200; 70069-065; 70069-066; 70069-067
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H27ClN2O
CAS Registry Number 98717-15-8
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abnormal labour18.07.02.001--Not Available
Accident12.01.08.001--Not Available
Acidosis14.01.03.002--
Acoustic stimulation tests abnormal13.07.01.004--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.003--
Albuminuria20.02.01.001--Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anterior spinal artery syndrome24.04.06.015; 17.10.01.008--Not Available
Anxiety19.06.02.002--
Apgar score low13.15.01.012--Not Available
Apnoea22.02.01.001--
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Arachnoiditis12.02.04.002; 17.06.01.001--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Blood creatine phosphokinase increased13.04.01.001--
Blood urea decreased13.13.01.017--Not Available
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