ADReCS

Pharmaceutical Information

Drug Name	Rivastigmine
Drug ID	BADD_D01955
Description	Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Indications and Usage	For the treatment of mild to moderate dementia associated with Parkinson's disease or of the Alzheimer's type.
Marketing Status	approved; investigational
ATC Code	N06DA03
DrugBank ID	DB00989
KEGG ID	D03822
MeSH ID	D000068836
PubChem ID	77991
TTD Drug ID	D0WY5Q
NDC Product Code	16714-117; 70710-1198; 72855-101; 0781-7304; 65372-1153; 82245-0107; 51956-0001; 51956-0002; 51991-898; 65162-826; 72855-102; 49706-1825; 0078-0503; 63629-2065; 65162-749; 65162-825; 0378-9072; 0781-7309; 12651-118; 64552-4021; 65015-819; 0078-0501; 63629-8846; 0378-9071; 70710-1196; 16714-115; 63629-2066; 50379-0014; 65862-982; 72855-100; 51956-0003; 51991-897; 51991-899; 0781-7313; 63629-2064; 0378-9070; 0078-0502; 16714-116; 63629-8807; 70710-1197
UNII	PKI06M3IW0
Synonyms	Rivastigmine \| (S)-N-Ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate \| RivastigmineTartrate \| Rivastigmine Hydrogen Tartrate \| Hydrogen Tartrate, Rivastigmine \| Tartrate, Rivastigmine Hydrogen \| Exelon \| ENA 713 \| 713, ENA \| SDZ ENA 713 \| 713, SDZ ENA \| ENA 713, SDZ \| ENA-713 \| ENA713

Chemical Information

Molecular Formula	C14H22N2O2
CAS Registry Number	123441-03-2
SMILES	CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal discomfort	07.01.06.001	0.002439%		Not Available
Abdominal distension	07.01.04.001	-	-
Abdominal pain	07.01.05.002	-	-
Abdominal pain upper	07.01.05.003	-	-
Abnormal dreams	19.02.03.001; 17.15.02.001	0.001463%		Not Available
Acute myocardial infarction	24.04.04.001; 02.02.02.001	0.000813%		Not Available
Acute respiratory failure	22.02.06.001; 14.01.04.004	0.000542%		Not Available
Aggression	19.05.01.001	0.006449%		Not Available
Agitation	19.06.02.001; 17.02.05.012	0.004065%
Akinesia	17.01.02.003	0.000542%		Not Available
Altered state of consciousness	19.07.01.003; 17.02.04.001	0.002168%		Not Available
Amnesia	19.20.01.001; 17.03.02.001	0.001897%
Anaemia	01.03.02.001	-	-
Anger	19.04.02.001	-	-	Not Available
Angina pectoris	24.04.04.002; 02.02.02.002	0.000542%
Anxiety	19.06.02.002	-	-
Apathy	19.04.04.002	0.000542%		Not Available
Aphasia	19.21.01.001; 17.02.03.001	0.002710%
Application site erythema	08.02.01.001; 23.03.06.005; 12.07.01.001	0.013874%		Not Available
Application site irritation	08.02.01.003; 12.07.01.003	0.004498%		Not Available
Application site pain	12.07.01.004; 08.02.01.004	0.001463%		Not Available
Application site pruritus	23.03.12.004; 12.07.01.005; 08.02.01.005	0.011923%		Not Available
Application site rash	12.07.01.016; 08.02.01.016; 23.03.13.008	0.008184%		Not Available
Application site reaction	12.07.01.006; 08.02.01.006	0.002656%		Not Available
Arrhythmia	02.03.02.001	0.001626%		Not Available
Arthropathy	15.01.01.003	-	-	Not Available
Asthenia	08.01.01.001	0.007046%		Not Available
Asthma	22.03.01.002; 10.01.03.010	0.000813%		Not Available
Atrial fibrillation	02.03.03.002	0.001355%
Atrioventricular block	02.03.01.002	0.001084%		Not Available

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