Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rivaroxaban
Drug ID BADD_D01954
Description Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Indications and Usage Not Available
Marketing Status Prescription
ATC Code B01AF01
DrugBank ID DB06228
KEGG ID D07086
MeSH ID D000069552
PubChem ID 9875401
TTD Drug ID D0KG3R
NDC Product Code 50090-3625; 50458-579; 50458-575; 65015-898; 58032-2029; 55154-1424; 53296-0109; 14799-2023; 55111-966; 76072-1008; 47848-039; 55154-1423; 14501-0079; 65727-050; 52286-0025; 59285-009; 65862-971; 16436-0109; 75945-050; 50090-4468; 53104-7730; 50090-3639; 53747-068; 66022-0203; 50090-4469; 50458-580; 64220-176; 63415-0523; 64552-4049; 50458-578; 46708-899; 82513-0001; 66174-0087; 72969-109; 66039-913; 50458-584; 65372-1193; 50458-577; 55154-1422; 69218-0500
Synonyms Rivaroxaban | 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide | Xarelto | BAY 59-7939 | BAY 59 7939 | BAY 597939
Chemical Information
Molecular Formula C19H18ClN3O5S
CAS Registry Number 366789-02-8
SMILES C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Spontaneous haemorrhage24.07.01.081; 01.01.03.0070.002142%Not Available
Splenic thrombosis24.01.08.006; 01.09.02.0180.000535%Not Available
Arterial intramural haematoma24.02.01.004; 12.02.01.0180.000357%Not Available
Internal haemorrhage24.07.01.0720.023023%Not Available
Cerebral ventricular rupture17.11.01.014; 12.01.10.0150.000791%Not Available
Chest wall haematoma24.07.01.065; 15.03.01.0230.001071%Not Available
Cerebral vascular occlusion24.04.06.035; 17.08.01.0490.000186%Not Available
Soft tissue swelling15.03.02.0200.000357%Not Available
Lacunar stroke24.04.06.037; 17.08.01.0540.001071%Not Available
Vein rupture24.03.02.032; 12.01.11.0110.000714%Not Available
Hemianaesthesia17.02.07.0210.000357%Not Available
End stage renal disease20.01.03.019--Not Available
Intracranial mass17.11.01.0170.000466%Not Available
Anti factor X activity increased13.01.02.0440.000535%Not Available
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