| Drug Name |
Risperidone |
| Drug ID |
BADD_D01951 |
| Description |
Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885]
Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively.[L1212,L1213] Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L1213,A1115]
Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors,[L1212,L1213,A1115] and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885] |
| Indications and Usage |
Risperidone is indicated for the treatment of schizophrenia and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885]
Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906]
Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226] |
| Marketing Status |
approved; investigational |
| ATC Code |
N05AX08 |
| DrugBank ID |
DB00734
|
| KEGG ID |
D00426
|
| MeSH ID |
D018967
|
| PubChem ID |
5073
|
| TTD Drug ID |
D01AZG
|
| NDC Product Code |
12578-303; 57451-1185; 64567-0003; 65757-728; 65862-365; 12496-0090; 13668-035; 13668-039; 50458-306; 50458-325; 51759-410; 55700-897; 59746-050; 65841-670; 68071-2706; 68084-277; 69238-2108; 70518-1613; 70518-2969; 70518-3741; 71610-045; 71610-246; 0615-8197; 0615-8265; 0904-6360; 63552-180; 42291-913; 49884-315; 51759-850; 55154-4161; 59746-010; 63304-950; 63629-2283; 68084-271; 68382-154; 69238-2113; 70518-1151; 55111-869; 65267-895; 65757-727; 27241-004; 27241-005; 27241-006; 42291-908; 50458-335; 50458-355; 51759-305; 51759-520; 58118-0077; 59746-040; 63629-2284; 65841-642; 65841-668; 0054-0063; 68084-270; 70518-0364; 70518-3087; 70518-3760; 55154-3361; 55154-5899; 63187-264; 63187-642; 63304-643; 65862-167; 68084-273; 71335-0130; 0615-8196; 0904-6358; 71161-131; 27241-003; 49884-403; 50458-302; 50458-308; 51759-960; 63187-439; 68382-155; 70518-1502; 71205-520; 71335-0626; 0904-6361; 65757-725; 13668-037; 27808-002; 43063-908; 43547-344; 49884-311; 49884-401; 54838-563; 59746-030; 63304-951; 65841-641; 65841-667; 68084-272; 70518-1574; 70518-1771; 71610-259; 0615-8198; 72526-102; 72526-104; 63415-0037; 63552-179; 64220-119; 64552-4011; 42291-911; 43547-343; 49884-402; 50458-300; 50458-315; 50458-395; 51759-630; 53002-1596; 65841-640; 65841-666; 68084-274; 68382-114; 68382-115; 70518-1575; 71610-264; 53104-7555; 65015-619; 65757-726; 65841-122; 12496-0120; 42291-909; 43063-254; 43353-412; 43353-720; 43547-339; 49884-212; 50090-3340; 50458-309; 50458-350; 51759-740; 59746-020; 62135-929; 63304-949; 68382-156; 70518-1568; 70518-1763; 71335-0459; 71335-0740; 0615-8288; 72526-103; 52038-007; 65372-1105; 27241-002; 43547-340; 43547-341; 43547-342; 50090-3344; 50458-305; 50458-307; 50458-596; 63187-418; 65162-673; 65841-669; 69238-2110; 70518-2130; 70518-3104; 0904-6359; 0904-6362; 13668-036; 13668-038; 27241-001; 42291-910; 42291-912; 43353-432; 50090-3341; 50458-320; 50458-330; 63304-644; 65841-665; 68382-112; 68382-113; 68382-116; 68382-117; 69238-2109; 69238-2111; 69238-2112; 70518-0978; 72162-2037; 72526-101; 0904-6357; 40700-0031; 46602-0050; 65267-303; 71161-132; 13668-040 |
| UNII |
L6UH7ZF8HC
|
| Synonyms |
Risperidone | Risperdal Consta | Consta, Risperdal | Risperidal | R-64,766 | R 64,766 | R64,766 | R-64766 | R 64766 | R64766 |
