Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status Prescription
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 70515-700; 35709-0003; 10094-350; 42291-775; 65129-1011; 63537-0066; 62756-983; 70726-0303; 68462-381; 0378-4145; 62756-538; 67877-286; 69076-200; 65977-0045; 63278-1076; 66039-812; 70510-2201
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholecystitis09.03.01.001--
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Condition aggravated08.01.03.004--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Congenital central nervous system anomaly17.19.01.003; 03.10.02.004--Not Available
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cor pulmonale24.08.03.001; 22.06.01.003; 02.05.03.001--Not Available
Cough22.02.03.0010.006536%
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Cyst16.02.02.002; 08.03.05.001--Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.0010.029667%
Dehydration14.05.05.001--
Delirium19.13.02.001--
Delusion19.10.01.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Dental caries07.09.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.002614%
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diabetes insipidus14.05.07.003; 05.03.03.004--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
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