Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status approved; investigational
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 68462-381; 70510-2201; 42291-775; 0378-4145; 62756-538; 67877-286; 69076-200; 63278-1076; 65129-1011; 70515-700; 65977-0045; 66039-812
UNII 7LJ087RS6F
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cheilitis23.03.03.025; 07.05.01.001--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholecystitis09.03.01.001--
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Condition aggravated08.01.03.0040.001077%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Congenital central nervous system anomaly17.19.01.003; 03.10.02.004--Not Available
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cor pulmonale24.08.03.001; 22.06.01.003; 02.05.03.001--Not Available
Cough22.02.03.0010.002799%
Cyanosis23.06.04.005; 02.11.04.004; 24.03.01.007; 22.02.02.007--
Cyst16.02.02.002; 08.03.05.001--Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.0010.027725%
Dehydration14.05.05.001--
Delirium19.13.02.001--
Delusion19.10.01.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Dental caries07.09.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000538%
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diabetes insipidus14.05.07.003; 05.03.03.004--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
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