Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranitidine
Drug ID BADD_D01913
Description Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.[L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries.[A176843] Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.[A176849,L10818]
Indications and Usage Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA02
DrugBank ID DB00863
KEGG ID D00422
MeSH ID D011899
PubChem ID 3001055
TTD Drug ID D0B8WN
NDC Product Code 66715-9736; 68196-985; 63629-8216; 43353-971; 68071-3162; 51407-245; 68071-5012; 50090-2740; 69842-871; 67751-151; 62207-773; 63629-1671; 50268-721; 65162-254; 49999-043; 67751-152; 68071-2185; 71335-0342; 45865-416; 71335-0042; 63868-480; 64380-937; 68071-3248; 70000-0033; 55111-131; 0904-6715; 64679-907; 64679-740; 71610-359; 68071-2190; 71335-1327; 27241-110; 27241-109; 30142-505; 63868-482; 71335-1621; 71335-0394; 62207-774; 71610-378; 71610-371; 69842-869; 55111-404; 68462-248; 53746-253; 53746-254; 0121-4727; 43598-808; 63629-8236; 43353-445; 11673-849; 0121-0727; 64679-906; 71713-203; 68071-5015; 65162-253; 64679-741; 68462-249; 67296-1586; 71610-362; 63629-7669; 64380-803; 65162-664; 51407-244; 43353-967; 71335-0363; 64380-804; 0904-6921; 64380-936; 63629-6757
Synonyms Ranitidine | Ranitidin | N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine | Biotidin | Ranisen | Sostril | Zantac | Zantic | AH-19065 | AH 19065 | AH19065 | Ranitidine Hydrochloride | Hydrochloride, Ranitidine
Chemical Information
Molecular Formula C13H22N4O3S
CAS Registry Number 82530-72-1
SMILES CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Vitamin B12 deficiencyCobalamin binding intrinsic factorP27352Not Available6135642; 6117373; 6768534; 6124297; 6126246; 1358279; 1775933; 6116636; 6119789; 6117040; 6134597
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gynaecomastia21.05.04.003; 05.05.02.003--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000105%Not Available
Haemoglobin decreased13.01.05.0030.000210%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate increased13.14.04.0020.000105%Not Available
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000157%
Hypersensitivity10.01.03.0030.000786%
Hypertension24.08.02.0010.000262%
Hypertensive crisis24.08.01.0010.000105%Not Available
Hyperuricaemia14.09.01.0030.000157%
Hypokalaemia14.05.03.0020.000105%
Hypopnoea22.02.01.0210.000105%Not Available
Hypotension24.06.03.0020.000891%
Hypothermia12.05.03.001; 08.05.01.0030.000157%
Hypovolaemia14.05.05.0020.000105%Not Available
Infection11.01.08.002--Not Available
Inflammatory bowel disease07.08.01.0160.000105%Not Available
Insomnia19.02.01.002; 17.15.03.0020.000576%
Interstitial lung disease22.01.02.003; 10.02.01.0330.000105%Not Available
Irritability19.04.02.013; 08.01.03.0110.000262%
Irritable bowel syndrome19.24.01.003; 07.02.04.0030.000105%Not Available
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
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