Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Raltegravir
Drug ID BADD_D01905
Description Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.
Indications and Usage For the treatment of HIV-1 infection in conjunction with other antiretrovirals.
Marketing Status Prescription
ATC Code J05AJ01
DrugBank ID DB06817
KEGG ID D06676
MeSH ID D000068898
PubChem ID 54671008
TTD Drug ID D0I1FQ
NDC Product Code 65977-0049; 70518-1621; 17381-749; 68071-2113; 0006-3080; 0006-0477; 0006-0473; 0006-0227; 50090-1085; 0006-3603
Synonyms Raltegravir Potassium | Potassium, Raltegravir | Raltegravir | MK 0518 | 0518, MK | MK0518 | MK-0518 | Isentress
Chemical Information
Molecular Formula C20H21FN6O5
CAS Registry Number 518048-05-0
SMILES CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancreatitis07.18.01.0010.018884%
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Patent ductus arteriosus24.03.03.002; 03.07.01.001; 02.08.01.0010.022661%Not Available
Pathogen resistance11.01.08.0490.003941%Not Available
Platelet count decreased13.01.04.001--
Pneumonia22.07.01.003; 11.01.09.0030.045323%Not Available
Pre-eclampsia20.01.08.002; 18.02.03.002; 24.08.07.0020.018884%Not Available
Premature baby18.04.02.0010.049100%Not Available
Premature delivery18.07.01.0060.026438%
Progressive multifocal leukoencephalopathy17.16.02.002; 11.05.05.0010.007554%Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyelonephritis20.01.09.001; 11.01.14.0020.007554%Not Available
Pyrexia08.05.02.0030.041546%
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.0040.018884%
Renal disorder20.01.02.0020.015108%Not Available
Renal failure20.01.03.0050.009853%Not Available
Respiratory distress22.02.01.0120.011331%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Rhabdomyolysis15.05.05.0020.022661%
Rhinorrhoea22.02.05.0100.007554%
Seizure17.12.03.001--
Sepsis11.01.11.0030.005912%
Septic shock24.06.02.011; 11.01.11.0040.001971%Not Available
Shock24.06.02.0020.001971%Not Available
Sinusitis22.07.03.007; 11.01.13.0050.011331%
Skin exfoliation23.03.07.0030.007554%Not Available
Somnolence17.02.04.006; 19.02.05.003--
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