Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole sodium
Drug ID BADD_D01899
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; Discontinued
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D00724
MeSH ID D064750
PubChem ID 14720269
TTD Drug ID D0KL4J
NDC Product Code 65372-1132; 70518-2590; 45865-802; 71335-0027; 72189-169; 50090-4751; 50090-1424; 71335-1558; 65862-721; 51407-184; 51148-005; 71205-603; 70518-3209; 60760-560; 51148-006; 50090-3145; 68788-7459; 52932-0736; 65862-414; 76420-107; 62856-243; 60760-972; 63187-555; 63187-788; 65977-0033; 50090-3430; 45865-123; 52286-0017; 80425-0134; 55700-767; 53069-0650; 72189-142; 71335-0244; 72888-059; 53104-7568; 71205-292; 55111-055; 80425-0094; 13668-107; 70518-2860; 68180-220; 50090-3182; 42765-013; 71335-0518; 67877-443; 61919-467; 63187-259; 68788-7657; 62175-302; 71335-1100; 53069-0980
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H20N3NaO3S
CAS Registry Number 117976-90-6
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Blood thyroid stimulating hormone increased13.10.03.006--
Coma17.02.09.001--Not Available
Constipation07.02.02.001--
Death08.04.01.001--
Delirium19.13.02.001--
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Erythema multiforme23.03.01.003; 10.01.03.015--
Flatulence07.01.04.002--
Fracture15.08.02.001; 12.04.02.001--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic encephalopathy17.13.01.003; 09.01.03.006--Not Available
Hepatitis09.01.07.004--Not Available
Hyperammonaemia14.10.01.001; 09.01.02.002--Not Available
Hypomagnesaemia14.04.02.001--
Infection11.01.08.002--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
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