Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status approved; investigational
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
UNII 32828355LL
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Colitis ulcerative10.02.01.004; 07.08.01.0050.000260%Not Available
Coma17.02.09.0010.000391%Not Available
Condition aggravated08.01.03.0040.000521%Not Available
Confusional state19.13.01.001; 17.02.03.0050.000521%
Congenital cystic kidney disease03.06.01.003; 20.01.04.006; 16.27.01.002--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.0010.000521%
Corneal opacity06.06.03.005--Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.000391%Not Available
Cystitis20.03.02.002; 11.01.14.001--
Deafness04.02.01.001--Not Available
Dehydration14.05.05.0010.000391%
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Dental caries07.09.01.001--
Dermatitis23.03.04.0020.000260%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.000391%Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.0010.002187%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disorientation17.02.05.015; 19.13.01.002--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.002499%
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug ineffective08.06.01.0060.006092%Not Available
Drug interaction08.06.03.0010.000651%Not Available
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