Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; Discontinued
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Congenital cystic kidney disease20.01.04.006; 16.27.01.002; 03.06.01.003--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Corneal opacity06.06.03.005--Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.001790%Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.001193%
Cystitis11.01.14.001; 20.03.02.002--
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.001--Not Available
Dental caries07.09.01.001--
Depression19.15.01.0010.001790%
Dermatitis23.03.04.0020.001193%Not Available
Dermatitis contact10.01.01.003; 23.03.04.004; 12.03.01.040--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.007159%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.002--Not Available
Diplopia06.02.06.002; 17.17.01.005--Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.004176%
Drug eruption08.01.06.015; 23.03.05.001; 10.01.01.005--Not Available
Drug hypersensitivity10.01.01.0010.002983%Not Available
Dry eye06.08.02.0010.001790%
Dry mouth07.06.01.0020.001193%
Dry skin23.03.03.001--
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