Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinine sulfate
Drug ID BADD_D01897
Description An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Indications and Usage For the treatment of malaria and leg cramps
Marketing Status Prescription
ATC Code P01BC01
DrugBank ID DB00468
KEGG ID D02262
MeSH ID D011803
PubChem ID 16211610
TTD Drug ID D03DDR
NDC Product Code 68428-310; 72282-0004; 68084-947; 49452-6210; 12065-1704; 0093-3002; 0220-1306; 67729-001; 0220-1311; 68180-560; 50742-238; 0220-1307; 0220-1325; 49708-153; 62106-5706; 53489-700; 0220-1310; 0220-1314
Synonyms Quinine | Quinimax | Quinine Bisulfate | Bisulfate, Quinine | Quinine Hydrochloride | Hydrochloride, Quinine | Myoquin | Quinamm | Quinbisan | Legatrim | Quinine Lafran | Quinine Sulfate | Sulfate, Quinine | Quinine Sulphate | Sulphate, Quinine | Quinine-Odan | Quinoctal | Surquina | Biquinate | Strema | Quindan | Quinbisul | Quinson | Quinsul
Chemical Information
Molecular Formula C40H54N4O10S
CAS Registry Number 804-63-7
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4 C=C)O.O.O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Vomiting07.01.07.003--
Mental status changes19.07.01.001--Not Available
Tubulointerstitial nephritis20.05.02.002--Not Available
Hypoacusis04.02.01.006--
Lupus-like syndrome23.03.02.004; 15.06.02.004; 10.04.03.003--Not Available
Epigastric discomfort07.01.02.004--Not Available
Electrocardiogram U-wave abnormality13.14.05.028--Not Available
Haemorrhage24.07.01.002--Not Available
Antiphospholipid antibodies13.06.01.007--Not Available
Extremity necrosis24.04.03.012--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal impairment20.01.03.010--Not Available
Immune thrombocytopenic purpura10.04.01.008; 01.08.01.007--Not Available
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